Assessment of Virological Contributions to COVID-19 Outcomes in a Longitudinal Cohort of Hospitalized Adults.
Lacy M SimonsRamon Lorenzo-RedondoMeg GibsonSarah L KinchJacob P VandervaartNina L ReiserMesut ErenElizabeth LuxElizabeth M McNallyAnat R TamburDouglas E VaughanKelly E R BachtaAlexis R DemonbreunKarla J F SatchellChad J AchenbachEgon A OzerMichael G IsonJudd F HultquistPublished in: Open forum infectious diseases (2022)
Ultimately, these results suggest that worse outcomes are driven by immune dysfunction rather than by viral load and that SARS-CoV-2 evolution in hospital settings is relatively constant over time.