Metal-Free Radical-Mediated C(sp3)-H Heteroarylation of Alkanes.

Xin ShaoXinxin WuShuo WuChen Zhu

Published in: Organic letters (2020)

Herein we disclose a metal-free, N/O-centered radical-promoted Minisci reaction, in which the coupling of various heteroarenes with simple alkanes proceeds under mild conditions. The reaction conditions are neutral; no extra acid is added to preactivate N-heteroarenes in the Minisci reaction. The N-/O-centered radicals are generated directly from amide (TsNHMe) or alcohol (CF3CH2OH) under visible-light irradiation. This green and eco-friendly synthetic process may find potential use in medicinal chemistry.

Keyphrases

visible light
room temperature
electron transfer
cystic fibrosis
human health
climate change
low cost
ionic liquid