Inhibition of p90 ribosomal S6 kinase potentiates cisplatin activity in A549 human lung adenocarcinoma cells.

Nabeel AbdulrahmanKodappully Sivaraman SiveenJensa Mariam JosephAisha Osman Huseyin Cagatay Yalcin Anwarul Hasan Shahab Uddin Fatima Mraiche

Published in: The Journal of pharmacy and pharmacology (2020)

These findings suggest that combining cisplatin with agents that target the RSK mediated cell survival pathway, may potentiate the cisplatin effect in lung adenocarcinoma.

Keyphrases

induced apoptosis
endothelial cells
cell cycle arrest
tyrosine kinase
induced pluripotent stem cells
oxidative stress
cell death
cell proliferation