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On-demand treatment with the iron chelator deferasirox is ineffective in preventing blood-induced joint damage in haemophilic mice.

Astrid E PullesLize F D van VulpenKatja CoeleveldSimon C MastbergenRoger E G SchutgensFloris P J G Lafeber
Published in: Haemophilia : the official journal of the World Federation of Hemophilia (2021)
On-demand treatment with DFX does not prevent joint damage following blood exposure in haemophilic mice. DFX seems unable to reach the joint in time to exert its effect before the irreversible harmful process is initiated.
Keyphrases
  • oxidative stress
  • high fat diet induced
  • type diabetes
  • diabetic rats
  • insulin resistance