Pyrimidine as an Aryl C-H Activating Group.
Sahaj GuptaJennifer A MelansonLouis VaillancourtWilliam A NugentGerald J TanouryGabriele SchatteVictor SnieckusPublished in: Organic letters (2018)
The Pd-catalyzed regioselective C-H activation/arylation, /iodination, and/acetoxylation reactions of 4-arylpyrimidines using aryl iodides, N-iodosuccinimide, and (diacetoxyiodo)benzene respectively as coupling partners are described. Suzuki-Miyaura coupling and Sonogashira reactions of the resulting aryl iodides are demonstrated. The scalability of the C-H activation/functionalization starting with readily accessible 4-aryl pyrimidines is also reported.