Transcriptomic modulation in response to high-intensity interval training in monocytes of older women with type 2 diabetes.

Jovane Hamelin MorrissetteDominic TremblayAlexis Marcotte-ChénardFarah LizotteMarie A BrunetBenoit LaurentEléonor RiescoPedro Geraldes

Published in: European journal of applied physiology (2022)

The downregulation of transcripts in monocytes globally suggests a favorable cardiovascular effect of the HIIT in older women with type 2 diabetes. In the context of precision medicine and personalized exercise prescription, shedding light on the fundamental mechanisms underlying HIIT effects on the gene profile of immune cells is essential to develop efficient nonpharmacological strategies to prevent CVD in high-risk population.

Keyphrases

high intensity
dendritic cells
peripheral blood
resistance training
cell proliferation
copy number
single cell
genome wide
signaling pathway
rna seq
physical activity
virtual reality