Salvianolic acid B as a potent nano-agent for enhanced ALA-PDT of oral cancer and leukoplakia cells.

Ying Zhang Sai YeYongmei ZhouZengtong ZhouYilin YaoWei Liu Lan Wu

Published in: Oral diseases (2023)

The novel photosensitizer nano-SalB-ALA remarkably enhanced the efficacy of PDT by improving singlet oxygen production, inhibiting cell proliferation, promoting cell apoptosis, and suppressing tumor growth. These suggest PDT with nano-SalB-ALA could be a clinically significant and potent treatment for oral cancer and leukoplakia.

Keyphrases

photodynamic therapy
cell proliferation
signaling pathway
induced apoptosis
cell cycle arrest
anti inflammatory
cell cycle
pi k akt
cell death
endoplasmic reticulum stress
smoking cessation