Candidate Genes Identified in Systemic Sclerosis-Related Pulmonary Arterial Hypertension Were Associated with Immunity, Inflammation, and Cytokines.
Zhixiao XuJiaxing RuanLingyun PanChengshui ChenPublished in: Cardiovascular therapeutics (2021)
The hub genes (BTG3, CCR2, RAB10, and TMEM60) performed well in distinguishing the SSc-PAH patients from controls, and some biological functions, related to immunity, inflammation, and cytokines, might pave the way for follow-up studies on the diagnosis and treatment of SSc-PAH.
Keyphrases
- systemic sclerosis
- pulmonary arterial hypertension
- end stage renal disease
- interstitial lung disease
- oxidative stress
- pulmonary hypertension
- pulmonary artery
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- dendritic cells
- genome wide
- regulatory t cells
- patient reported outcomes
- transcription factor
- dna methylation
- network analysis