Intravitreal Injection of Hydrogen Peroxide Induces Acute Retinal Degeneration, Apoptosis, and Oxidative Stress in Mice.
Bing HuangJia-Jian LiangXi ZhuangShao-Wan ChenTsz Kin NgHaoyu ChenPublished in: Oxidative medicine and cellular longevity (2018)
This study revealed that intravitreal injection of H2O2 induces acute retinal damage by increasing oxidative stress and cell apoptosis in the retina. This acute retinal degeneration mouse model could provide a platform for drug screening against oxidative stress and retinal diseases.
Keyphrases
- oxidative stress
- diabetic retinopathy
- optical coherence tomography
- hydrogen peroxide
- liver failure
- optic nerve
- respiratory failure
- drug induced
- dna damage
- mouse model
- ischemia reperfusion injury
- diabetic rats
- induced apoptosis
- aortic dissection
- vascular endothelial growth factor
- hepatitis b virus
- ultrasound guided
- endoplasmic reticulum stress
- emergency department
- type diabetes
- metabolic syndrome
- cell death
- age related macular degeneration
- high throughput
- adverse drug
- heat shock
- skeletal muscle
- extracorporeal membrane oxygenation
- insulin resistance
- adipose tissue
- cell cycle arrest
- high fat diet induced
- endothelial cells