Approach Matters: The Kinetics of Interfacial Inverse-Electron Demand Diels-Alder Reactions.

Rickdeb Sen Digvijay Gahtory Jorge EscorihuelaJudith FiretSidharam Pundlik Pujari Han Zuilhof

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2017)

Rapid and quantitative click functionalization of surfaces remains an interesting challenge in surface chemistry. In this regard, inverse electron demand Diels-Alder (IEDDA) reactions represent a promising metal-free candidate. Herein, we reveal quantitative surface functionalization within 15 min. Furthermore, we report the comprehensive effects of substrate stereochemistry, surrounding microenvironment and substrate order on the reaction kinetics as obtained by surface-bound mass spectrometry (DART-HRMS).

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