IgG1+ B-cell immunity predates IgE responses in epicutaneous sensitization to foods.

Rodrigo Jiménez-SaizY EllenbogenJ F E KoenigM E GordonT D WalkerD RosaceP SpillK BrutonJ KongK MonteiroJ WenE I TuomanenR KolbeckD K ChuS WasermanM Jordana

Published in: Allergy (2018)

Our data demonstrate that IgG1+ B-cell immunity against food allergens in epicutaneous sensitization precedes the generation of IgE responses. Therefore, the assessment of allergen-specific cellular and humoral IgG1+ immunity may help to identify individuals at risk of developing IgE-mediated food allergy and hence provide a window for therapeutic interventions.

Keyphrases

immune response
electronic health record
big data
machine learning
data analysis
atopic dermatitis