The environmental pollutant, polychlorinated biphenyl 126, alters liver function in a rodent model of alcohol-associated liver disease.
Tyler C GripshoverBanrida WahlangKimberly Z HeadJamie L YoungJianzhu LuoMuhammad T MustafaIrina A KirpichMatthew C CavePublished in: Alcoholism, clinical and experimental research (2022)
Various environmental toxicants are known to modify or enhance FLD in high-fat diet models. Findings from the present study suggest that they interact with other lifestyle factors such as alcohol consumption to reprogram intermediary metabolism resulting in exacerbated ethanol-associated systemic malnutrition in ALD.