Re-positioning of low dose paclitaxel against depressive-like behavior and neuroinflammation induced by lipopolysaccharide in rats: Crosstalk between NLRP3/caspase-1/IL-1β and Sphk1/S1P/ NF-κB signaling pathways.
Asmaa S ElzaitonyAya H Al-NajjarAsmaa A GomaaAyat M S EraqueAmany Said SallamPublished in: Toxicology and applied pharmacology (2024)
These findings prove the role of low-dose PXL in treatment of LPS-induced neuroinflammation and depressive-like behavior through their anti-depressant, antioxidant and anti-inflammatory actions. The suggested molecular mechanism may entail focusing the interconnection among Sphk1/S1P, and NLRP3/caspase-1/IL-1β signaling pathways. Hence PXL could be used as a novel treatment against LPS-induced depression.
Keyphrases
- lps induced
- inflammatory response
- low dose
- signaling pathway
- anti inflammatory
- cell death
- lipopolysaccharide induced
- induced apoptosis
- high dose
- bipolar disorder
- depressive symptoms
- toll like receptor
- oxidative stress
- pi k akt
- traumatic brain injury
- stress induced
- immune response
- epithelial mesenchymal transition
- physical activity
- brain injury
- blood brain barrier
- smoking cessation
- cerebral ischemia