Immunohistochemical expression of Cyclin D1 among Sudanese patients diagnosed with benign and malignant prostatic lesions.

Eiman Siddig AhmedLubna S ElnourRowa HassanEmmanuel E SiddigMintu Elsa ChackoEman T AliMona A MohamedAbdalla MunirMohamed S MuneerNouh Saad MohamedAli M M Edris

Published in: BMC research notes (2020)

A total of 153 males' prostate sections included in this study, of them, 120 (78.4%) were PC, and 33 (21.6%) were BPH. Their age ranged from 45 to 88 years, mean age was 66.19 ± 8.599. 142 (92.8%) did not have a family history of PC, while 11 (7.2%) patients reported having a family history. The Gleason scoring showed a total of 81 (52.9%) patients with high-grade and 39 (25.5%) with low-grade. 118 (97.5%) patients had PC showed positive results for Cyclin D1, while BPH was 3 (2.5%). P value < 0.001. Cyclin D1 staining was associated with high-grade Gleason score and perineural invasion, P value 0.001.

Keyphrases

high grade
low grade
end stage renal disease
prostate cancer
ejection fraction
newly diagnosed
prognostic factors
benign prostatic hyperplasia
radical prostatectomy
patient reported outcomes
cell proliferation