Systemic Catecholaminergic Deficiency in Depressed Patients with and without Coronary Artery Disease.
Uta HoppmannHarald EnglerSabrina KrauseEdit RottlerJulia HoechFranziska SzaboPeter RadermacherChristiane WallerPublished in: Journal of clinical medicine (2021)
The stress response of the CA system was not affected by depression or CAD, whereas at baseline we detected a depression-related reduction of epinephrine and dopamine release independent of CAD comorbidity. Reduced norepinephrine and dopamine secretion in the central nervous system in depression, known as 'CA-deficit hypothesis', are targets of antidepressant drugs. Our results point towards a CA-deficit in the peripheral nervous system in line with CA-deficit of the central nervous system and CA exhaustion in depression. This might explain somatic symptoms such as constipation, stomach pain, diarrhoea, sweating, tremor, and the influence of depression on the outcome of somatic illness such as CAD.
Keyphrases
- coronary artery disease
- depressive symptoms
- sleep quality
- protein kinase
- chronic pain
- percutaneous coronary intervention
- cardiovascular disease
- coronary artery bypass grafting
- cardiovascular events
- uric acid
- deep brain stimulation
- heart failure
- dna methylation
- gene expression
- copy number
- metabolic syndrome
- major depressive disorder
- spinal cord injury
- cerebrospinal fluid
- spinal cord
- left ventricular
- bipolar disorder
- aortic valve
- transcatheter aortic valve replacement