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A New Glucosyl Flavone with Inhibitory Activity of Cancer Cell Viability and Other Bioactive Constituents from the Traditional Kurdish Plant Plantago loeflingii L.

Hawraz Ibrahim M AminKamaran Younis M AminChabaco ArmijosFaiq H S HussainZanko Hassan JawharDiego CaprioglioMariella MellaGiovanni Vidari
Published in: Molecules (Basel, Switzerland) (2024)
A new glucosyl flavone, 5,7,2',5'-tetrahydroxyflavone 7- O -β-d-glucopyranoside, named loeflingiin, together with apigenin 6- C -glucoside (isovitexin), coumarins citropten and isompinellin, triterpenoids betulin and betulinic acid, and a mixture of phytosterols β-sitosterol, stigmasterol and campesterol were isolated for the first time from the leaves of wild Plantago loeflingii L. ( Plantaginaceae ) collected in the Iraqi Kurdistan region. The plant is used by local people to treat wounds and as a vulnerary remedy. The structures of isolated compounds were determined by spectroscopic analysis. The activities of isovitexin and loeflingiinon the viability of breast (MCF7), ovarian (BG-1), endometrial (Ishikawa), and mesothelioma (IST-MES1) human cancer cells and two normal cell lines were determined with an MTT assay. Notably, the new 7- O -glucosyl flavone showed effects higher than cisplatin against the Ishikawa and IST-MESI cell lines. The significant biological activities exhibited by all the compounds isolated from P. loeflingii provided scientific evidence to support the use of the plant in the Kurdish traditional medicine.
Keyphrases
  • endothelial cells
  • cell wall
  • molecular docking
  • high resolution
  • high throughput
  • breast cancer cells
  • squamous cell carcinoma
  • induced pluripotent stem cells
  • essential oil
  • young adults
  • data analysis