Development and Validation of a High-Performance Liquid Chromatography-Ultraviolet Spectrometry Method for Ampicillin and its Application in Routine Therapeutic Drug Monitoring of Intensive Care Patients.
Benedict MorathLinda SchultesOtto Roman FreyAnka Christa RöhrHannes ChristowTorsten Hoppe-TichyAlexander BrinkmannUte BlassmannPublished in: Therapeutic drug monitoring (2024)
This method provides a practical solution for the routine TDM of ampicillin, facilitating individualized dosing strategies to ensure adequate therapeutic drug exposure. Given its simplicity, cost-effectiveness, and clinical relevance, HPLC-ultraviolet spectrometry holds promise for broad implementation in hospital pharmacies and clinical laboratories.
Keyphrases
- high performance liquid chromatography
- solid phase extraction
- simultaneous determination
- tandem mass spectrometry
- end stage renal disease
- mass spectrometry
- healthcare
- high resolution
- ejection fraction
- gas chromatography
- clinical practice
- ms ms
- chronic kidney disease
- primary care
- prognostic factors
- peritoneal dialysis
- machine learning
- patient reported outcomes
- quality improvement
- patient reported