Colonic Epithelial PHLPP2 Deficiency Promotes Colonic Epithelial Pyroptosis by Activating the NF-κB Signaling Pathway.

De-Feng LiXin ChangJiu-Long ZhaoXuan-Min ChenZheng-Lei XuDing-Guo ZhangBen-Hua Wu Li-Sheng Wang Zhaoshen Li Jun Yao

Published in: Oxidative medicine and cellular longevity (2021)

PHLPP2 downexpression activated the NF-κB signaling and promoted the IEC pyroptosis, leading to UC progression. Therefore, PHLPP2 might be an attractive candidate therapeutic target for UC.

Keyphrases

signaling pathway
pi k akt
nlrp inflammasome
induced apoptosis
epithelial mesenchymal transition
ulcerative colitis
lps induced
oxidative stress
immune response
nuclear factor
cell proliferation