Temporal Dynamics of the Scale for the Assessment and Rating of Ataxia in Spinocerebellar Ataxias.

Paul MoulairePierre Emmanuel PouletEmilien PetitThomas KlockgetherAlexandra DurrTetsuo Ashizawa Sophie Tezenas Du Montcelnull null

Published in: Movement disorders : official journal of the Movement Disorder Society (2022)

Despite a heterogeneous temporal dynamics at the item level, the global progression of SARA was linear. Changing the initial scale deteriorates the responsiveness. This new information about the temporal dynamics of the scale should help design the outcome of future clinical trials. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

clinical trial
early onset
healthcare
psychometric properties
study protocol
phase ii
phase iii
meta analyses