Hallmarks of frailty and osteosarcopenia in prematurely aged PolgA(D257A/D257A) mice.

Ariane C ScheurenGommaar D'HulstGisela A KuhnEvi MasscheleinEsther WehrleKatrien De BockRalph Müller

Published in: Journal of cachexia, sarcopenia and muscle (2020)

PolgA(D257A/D257A) mutation leads to hallmarks of age-related frailty and osteosarcopenia and provides a powerful model to better understand the relationship between frailty and the aging musculoskeletal system.

Keyphrases

community dwelling
high fat diet induced
type diabetes
metabolic syndrome
adipose tissue
wild type