Hallmarks of frailty and osteosarcopenia in prematurely aged PolgA(D257A/D257A) mice.
Ariane C ScheurenGommaar D'HulstGisela A KuhnEvi MasscheleinEsther WehrleKatrien De BockRalph MüllerPublished in: Journal of cachexia, sarcopenia and muscle (2020)
PolgA(D257A/D257A) mutation leads to hallmarks of age-related frailty and osteosarcopenia and provides a powerful model to better understand the relationship between frailty and the aging musculoskeletal system.