Diclofenac attenuates inflammation through TLR4 pathway and improves exercise performance after exhaustive swimming.

Flávia M Steckling Frederico D Lima Juliano Boufleur Farinha Pamela Carvalho Rosa Luiz Fernando Freire Royes María J Cuevas Guilherme Bresciani Felix Alexandre Antunes Soares Javier Gonzalez-Gallego Rômulo Pillon Barcelos

Published in: Scandinavian journal of medicine & science in sports (2019)

Our findings suggest that diclofenac may improve exercise performance and represent an effective tool to ameliorate the pro-inflammatory status in liver when associated with exhaustive exercise, and the liver may be a possible therapeutic target.

Keyphrases

high intensity
physical activity
resistance training
oxidative stress
inflammatory response
immune response
toll like receptor