A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.

Ali Amin Al OlamaZsofia Kote-JaraiSonja I BerndtDavid V ContiFredrick SchumacherYing HanSara BenllochDennis J HazelettZhaoming WangEd SaundersDaniel A LeongamornlertSara LindstromSara Jugurnauth-LittleTokhir DadaevMalgorzata TymrakiewiczDaniel O StramKristin RandPeggy WanAlex StramXin ShengLoreall C PoolerKaren ParkLucy XiaJonathan TyrerLaurence N KolonelLoic Le MarchandRobert N HooverMitchell J MachielaMerideth YeagerLaurie BurdetteCharles C ChungAmy HutchinsonKai YuChee GohMahbubl AhmedKoveela GovindasamiMichelle GuyTeuvo L J TammelaAnssi AuvinenTiina WahlforsJohanna SchleutkerTapio VisakorpiKatri A LeinonenJianfeng XuMarkus AlyJenny DonovanRuth C TravisTim J KeyAfshan SiddiqFederico CanzianKay-Tee KhawAtsushi TakahashiMichiaki KuboPaul PharoahNora PashayanMaren WeischerBorge G NordestgaardSune F NielsenPeter KlarskovMartin Andreas RøderPeter IversenStephen N ThibodeauShannon K McDonnellDaniel J SchaidJanet L StanfordSuzanne KolbSarah HoltBeatrice KnudsenAntonio Hurtado CollSusan M GapsturW Ryan DiverVictoria L StevensChristiane MaierManuel LuedekeKathleen HerkommerAntje E RincklebSara S StromCurtis PettawayEdward D YeboahYao TetteyRichard B BiritwumAndrew A AdjeiEvelyn TayAnn TrueloveShelley NiwaAnand P ChokkalingamLisa Cannon-AlbrightCezary CybulskiDominika WokołorczykWojciech KluźniakJong ParkThomas SellersHui-Yi LinWilliam B IsaacsAlan W PartinHermann BrennerAida Karina DieffenbachChrista StegmaierConstance ChenEdward L GiovannucciJing MaMeir StampferKathryn L PenneyLorelei MucciEsther M JohnSue A InglesRick A KittlesAdam B MurphyHardev PandhaAgnieszka MichaelAndrzej M KierzekWilliam BlotLisa B SignorelloWei ZhengDemetrius AlbanesJarmo VirtamoStephanie WeinsteinBarbara NemesureJohn CarptenCristina LeskeSuh-Yuh WuAnselm HennisAdam S KibelBenjamin A RybickiChristine Neslund-DudasAnn W HsingLisa ChuPhyllis J GoodmanEric A KleinS Lilly ZhengJyotsna BatraJudith ClementsAmanda SpurdleManuel R TeixeiraPaula PauloSofia MaiaChavdar SlavovRadka KanevaVanio MitevJohn S WitteGraham CaseyElizabeth M GillandersDaniella SeminaraElio RiboliFreddie C HamdyGerhard A CoetzeeQiyuan LiMatthew L FreedmanDavid J HunterKenneth MuirHenrik GronbergDavid E NealMelissa SoutheyGraham G GilesGianluca Severinull nullnull nullnull nullnull nullMichael B CookHidewaki NakagawaFredrik WiklundPeter KraftStephen J ChanockBrian E HendersonDouglas F EastonRosalind A EelesChristopher A Haiman

Published in: Nature genetics (2014)

Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of > 10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10(-8); 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.

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