Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis.
Fabia de Oliveira AndradeVivek VermaLeena Hilakivi-ClarkePublished in: Cancer reports (Hoboken, N.J.) (2022)
Since immunotherapies have emerged as highly effective treatments for many cancers, albeit there is an urgent need to enlarge the patient population who will be responsive to these treatments. One of the factors which may cause ICB refractoriness could be maternal obesity, based on its effects on the microbiota markers of ICB therapy response among the offspring. Since about 40% of children are born to obese mothers in the Western societies, it is important to determine if maternal obesity impairs offspring's response to cancer immunotherapies.
Keyphrases
- weight loss
- metabolic syndrome
- insulin resistance
- birth weight
- high fat diet
- weight gain
- type diabetes
- high fat diet induced
- adipose tissue
- pregnancy outcomes
- gestational age
- bariatric surgery
- young adults
- south africa
- body mass index
- skeletal muscle
- cancer therapy
- childhood cancer
- low birth weight
- squamous cell
- bone marrow
- obese patients
- preterm infants
- smoking cessation