Partially hydrolyzed guar gum suppresses the progression of pulmonary arterial hypertension in a SU5416/hypoxia rat model.

Takayuki Jujo SanadaKoji HosomiJonguk ParkAkira NaitoSeiichiro SakaoNobuhiro TanabeJun KunisawaKoichiro TatsumiTakuji Suzuki

Published in: Pulmonary circulation (2023)

This study investigated the effects of partially hydrolyzed guar gum (PHGG) on the development of pulmonary arterial hypertension using a SU5416/hypoxia rat model. Our results demonstrated that PHGG treatment suppressed the development of pulmonary hypertension and vascular remodeling with an altered gut microbiota composition.

Keyphrases

pulmonary arterial hypertension
pulmonary hypertension
pulmonary artery
endothelial cells
signaling pathway
coronary artery
combination therapy
smoking cessation