Effectiveness and safety of the combination of sodium-glucose transport protein 2 inhibitors and glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of observational studies.

Published in: Cardiovascular diabetology (2024)

This systematic review and meta-analysis based on real-world data suggests that the combination of SGLT2is + GLP-1RAs is associated with lower all-cause mortality and favorable improvements in cardiovascular, renal, and glycemic measurements. The findings drive a call-to-action to incorporate this combination early and simultaneously in managing T2DM patients and achieve potential cardiovascular benefits and renal protection.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
type diabetes
peritoneal dialysis
prognostic factors
metabolic syndrome
protein protein
artificial intelligence
adipose tissue
deep learning
wild type