A Real-world Toxicity Atlas Shows that Adverse Events of Combination Therapies Commonly Result in Additive Interactions.

Asli Küçükosmanoglu Silvia Scoarta Megan Houweling Nicoleta Spinu Thomas Wijnands Niek Geerdink Carolien Meskers Georgi K Kanev Bert Kiewiet Mathilde C M Kouwenhoven David P Noske Tom Wurdinger Marianne G Pouwer Mark Wolff Bart A Westerman

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Our study provides a framework for analyzing adverse events and suggests that adverse drug interactions commonly result in additive effects with a high level of overlap of adverse event patterns. These real-world insights may advance the implementation of new combination therapies in clinical practice.

Keyphrases

adverse drug
clinical practice
primary care
healthcare
electronic health record
emergency department
oxidative stress
drug induced