Relationship Between White Matter Lesions and Gray Matter Atrophy in Multiple Sclerosis: A Systematic Review.
Ingrid Anne LieMerlin M WeedaRozemarijn M MattiesingMarijke A E MolPetra J W PouwelsFrederik BarkhofØivind TorkildsenLars BøKjell-Morten MyhrHugo VrenkenPublished in: Neurology (2022)
The findings suggest that GM neurodegeneration is mostly secondary to damage in the WM during early disease stages while becoming more detached and dominated by other, possibly primary neurodegenerative disease mechanisms in progressive MS.