Paracrine regulation of somatostatin secretion by insulin and glucagon in mouse pancreatic islets.
Berit SvendsenJens Juul HolstPublished in: Diabetologia (2020)
Our findings demonstrate that somatostatin and glucagon secretion are linked in a reciprocal feedback cycle with somatostatin inhibiting glucagon secretion at low and high glucose levels, and glucagon stimulating somatostatin secretion via the glucagon and GLP-1 receptors. Graphical abstract.