Genetic variants in DNMT1 and the risk of cardiac autonomic neuropathy in women with type 1 diabetes.
Daniele Pereira Santos-BezerraSharon Nina AdmoniRosana Cristina MoriTatiana Souza PelaesRicardo Vesoni PerezCleide Guimarães MachadoMaria Beatriz MonteiroMaria Candida ParisiElizabeth Joao PavinMarcia Silva QueirozMarisa PassarelliUbiratan Fabres MachadoMaria Lúcia Cardillo Côrrea-GiannellaPublished in: Journal of diabetes investigation (2019)
The fact that heterozygous mutations in DNMT1 are associated with hereditary sensory autonomic neuropathy provides plausibility to the present finding. If confirmed in independent samples, it suggests that genetic variants in epigenetic genes might predispose to more or fewer epigenetic changes in the face of similar metabolic derangements triggered by hyperglycemia, constituting the "genetics of epigenetics" for microvascular diabetes complications.
Keyphrases
- dna methylation
- genome wide
- heart rate variability
- heart rate
- gene expression
- type diabetes
- polycystic ovary syndrome
- cardiovascular disease
- early onset
- left ventricular
- glycemic control
- risk factors
- pregnancy outcomes
- blood pressure
- heart failure
- oxidative stress
- bioinformatics analysis
- skeletal muscle
- metabolic syndrome
- insulin resistance
- genome wide analysis
- genome wide identification
- transcription factor
- breast cancer risk
- adipose tissue