Light-Induced Chiral Iron Copper Selenide Nanoparticles Prevent β-Amyloidopathy In Vivo.
Hongyu ZhangChanglong HaoAihua QuMaozhong SunLiguang XuChuanlai XuHua KuangPublished in: Angewandte Chemie (International ed. in English) (2020)
The accumulation and deposition of β-amyloid (Aβ) plaques in the brain is considered a potential pathogenic mechanism underlying Alzheimer's disease (AD). Chiral l/d-Fex Cuy Se nanoparticles (NPs) were fabricated that interfer with the self-assembly of Aβ42 monomers and trigger the Aβ42 fibrils in dense structures to become looser monomers under 808 nm near-infrared (NIR) illumination. d-Fex Cuy Se NPs have a much higher affinity for Aβ42 fibrils than l-Fex Cuy Se NPs and chiral Cu2-x Se NPs. The chiral Fex Cuy Se NPs also generate more reactive oxygen species (ROS) than chiral Cu2-x Se NPs under NIR-light irradiation. In living MN9D cells, d-NPs attenuate the adhesion of Aβ42 to membranes and neuron loss after NIR treatment within 10 min without the photothermal effect. In-vivo experiments showed that d-Fex Cuy Se NPs provide an efficient protection against neuronal damage induced by the deposition of Aβ42 and alleviate symptoms in a mouse model of AD, leading to the recovery of cognitive competence.
Keyphrases
- oxide nanoparticles
- photodynamic therapy
- capillary electrophoresis
- reactive oxygen species
- ionic liquid
- mouse model
- drug release
- induced apoptosis
- cell death
- escherichia coli
- drug delivery
- dna damage
- cell cycle arrest
- room temperature
- radiation therapy
- risk assessment
- resting state
- signaling pathway
- cancer therapy
- metal organic framework
- human health
- radiation induced
- combination therapy
- functional connectivity