Probiotic-derived nanoparticles inhibit ALD through intestinal miR194 suppression and subsequent FXR activation.
Mengwei JiangFengyuan LiYunhuan LiuZelin GuLihua ZhangJiyeon LeeLiqing HeVatsalya VatsalyaHuang-Ge ZhangZhongbin DengXiang ZhangShao-Yu ChenGrace L GuoShirish BarveCraig J McClainWenke FengPublished in: Hepatology (Baltimore, Md.) (2022)
Our results demonstrated that gut microbiota-mediated miR194 regulation contributes to ALD pathogenesis and to the protective effects of LDNPs through modulating intestinal FXR signaling.