Altered Patterns of Brain Glucose Metabolism Involve More Extensive and Discrete Cortical Areas in Treatment-resistant Schizophrenia Patients Compared to Responder Patients and Controls: Results From a Head-to-Head 2-[18F]-FDG-PET Study.
Felice IasevoliLuigi D'AmbrosioMariateresa CiccarelliAnnarita BaroneValeria GaudieriSirio CocozzaGiuseppe PontilloArturo BrunettiAlberto CuocoloAndrea de BartolomeisSabina PappatàPublished in: Schizophrenia bulletin (2022)
These data indicate that, in TRS patients, altered metabolism involved discrete brain regions not found affected in nTRS, possibly indicating a more severe disrupted functional brain network associated with disorganization symptoms.