Transcriptional consequences of trisomy 21 on neural induction.
José L MartinezJennifer G PiciwMadeline CrockettIsabella A SorciNikunj MakwanaCarissa L SiroisYathindar Giffin-RaoAnita Bhattacharyya
Published in: Frontiers in cellular neuroscience (2024)
Trisomy 21 impacts discrete developmental pathways at the earliest stages of neural development. The results suggest that metabolic dysfunction arises early in embryogenesis in trisomy 21 and may affect development and function more broadly.