Potentiation of cognitive enhancer effects of Alzheimer's disease medication memantine by alpha7 nicotinic acetylcholine receptor agonist PHA-543613 in the Morris water maze task.

Nóra BrusztZsolt Kristóf BaliSai Ambika TadepalliLili Veronika NagyIstván Hernádi

Published in: Psychopharmacology (2021)

Our results further support the evidence of beneficial interactions between memantine and alpha7 nAChR ligands and suggest a prominent role of alpha7 nAChRs in the procognitive effects of memantine.

Keyphrases

healthcare
cognitive decline
emergency department
binding protein
mild cognitive impairment