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Whole-genome sequence-informed MALDI-TOF MS diagnostics reveal importance of Klebsiella oxytoca group in invasive infections: a retrospective clinical study.

Aline CuénodDaniel WüthrichHelena M B Seth-SmithChantal OttChristian GehringerFrédéric FoucaultRoxanne MouchetAli KassimGunturu RevathiDeborah R VogtStefanie von FeltenStefano BassettiSarah Tschudin-SutterTimm HettichGötz SchlotterbeckChristina HombergerCarlo CasanovaJacob Moran-GiladOrli SagiBelén Rodríguez-SánchezFranco MüllerMartina AerniValeria GaiaHelke van DesselGreetje A KampingaClaudia MüllerClaudia DaubenbergerValentin PflügerAdrian Egli
Published in: Genome medicine (2021)
Currently misdiagnosed Klebsiella spp. can be distinguished using a ribosomal marker-based approach for MALDI-TOF MS. Klebsiella groups and species differed in AMR profiles, and in their association with invasive infection, highlighting the importance for species identification to enable effective treatment options.
Keyphrases
  • mass spectrometry
  • genome wide
  • single cell
  • gene expression
  • dna methylation
  • amino acid
  • antimicrobial resistance