Whole-genome sequence-informed MALDI-TOF MS diagnostics reveal importance of Klebsiella oxytoca group in invasive infections: a retrospective clinical study.

Aline CuénodDaniel WüthrichHelena M B Seth-SmithChantal OttChristian GehringerFrédéric FoucaultRoxanne MouchetAli KassimGunturu RevathiDeborah R VogtStefanie von FeltenStefano BassettiSarah Tschudin-SutterTimm HettichGötz SchlotterbeckChristina HombergerCarlo CasanovaJacob Moran-GiladOrli SagiBelén Rodríguez-SánchezFranco MüllerMartina AerniValeria GaiaHelke van DesselGreetje A KampingaClaudia MüllerClaudia DaubenbergerValentin PflügerAdrian Egli

Published in: Genome medicine (2021)

Currently misdiagnosed Klebsiella spp. can be distinguished using a ribosomal marker-based approach for MALDI-TOF MS. Klebsiella groups and species differed in AMR profiles, and in their association with invasive infection, highlighting the importance for species identification to enable effective treatment options.

Keyphrases

mass spectrometry
genome wide
single cell
gene expression
dna methylation
amino acid
antimicrobial resistance