Routes to Potentially Safer T1 Magnetic Resonance Imaging Contrast in a Compact Plasmonic Nanoparticle with Enhanced Fluorescence.
Luke HendersonOara NeumannCaterina KaffesRunmin ZhangValeria MarangoniMurali K RavooriVikas KundraJames BanksonPeter J NordlanderNaomi J HalasPublished in: ACS nano (2018)
Engineering a compact, near-infrared plasmonic nanostructure with integrated image-enhancing agents for combined imaging and therapy is an important nanomedical challenge. Recently, we showed that Au@SiO2@Au nanomatryoshkas (NM) are a highly promising nanostructure for hosting either T1 MRI or fluorescent contrast agents with a photothermal therapeutic response in a compact geometry. Here, we show that a near-infrared-resonant NM can provide simultaneous contrast enhancement for both T1 magnetic resonance imaging (MRI) and fluorescence optical imaging (FOI) by encapsulating both types of contrast agents in the internal silica layer between the Au core and shell. We also show that this method of T1 enhancement is even more effective for Fe(III), a potentially safer contrast agent compared to Gd(III). Fe-NM-based contrast agents are found to have relaxivities 2× greater than those found in the widely used gadolinium chelate, Gd(III) DOTA, providing a practical alternative that would eliminate Gd(III) patient exposure entirely. This dual-modality nanostructure can enable not only tissue visualization with MRI but also fluorescence-based nanoparticle tracking for quantifying nanoparticle distributions in vivo, in addition to a near-infrared photothermal therapeutic response.
Keyphrases
- contrast enhanced
- magnetic resonance imaging
- magnetic resonance
- photodynamic therapy
- computed tomography
- diffusion weighted imaging
- single molecule
- energy transfer
- high resolution
- sensitive detection
- drug delivery
- quantum dots
- deep learning
- metal organic framework
- bone marrow
- high speed
- stem cells
- case report
- pet ct
- mass spectrometry
- fluorescence imaging
- label free