Low flow rate alters haemostatic parameters in an ex-vivo extracorporeal membrane oxygenation circuit.

Katrina K KiMargaret R PassmoreChris H H ChanMaximilian V MalfertheinerJonathon P FanningMahé BouquetJonathan E MillarJohn F FraserJacky Y Suen

Published in: Intensive care medicine experimental (2019)

In an ex-vivo model of ECMO, low-flow rate (1.5 L/min) altered haemostatic parameters compared to high-flow (4 L/min). Observed differences in haemolysis, ristocetin-induced platelet aggregation, high-molecular-weight vWF multimers and clot formation time suggest an increased risk of bleeding complications. Since patients are often on ECMO for protracted periods, extended-duration studies are required to characterise long-term ECMO-induced haemostatic changes.

Keyphrases

extracorporeal membrane oxygenation
acute respiratory distress syndrome
respiratory failure
high glucose
end stage renal disease
diabetic rats
chronic kidney disease
ejection fraction
newly diagnosed
drug induced
endothelial cells
oxidative stress
risk factors
patient reported outcomes
patient reported