Fast detection of hypobromous acid in cells and the water environment using a lysosome-targeted fluorescent probe.
Quan-Rong DuMin PengYang TianXue YaoJianfeng ZhengYu PengYa-Wen WangPublished in: Organic & biomolecular chemistry (2024)
A new fluorescent probe SWJT-23 with lysosomal targeting ability for detection of hypobromous acid (HBrO) was synthesised based on the naphthalimide skeleton. This probe exhibited a fast response (within 3s), a low detection limit (1.24 nM), excellent selectivity and a high fluorescence quantum yield ( Φ = 0.490). Moreover, SWJT-23 not only realized the sensitive detection of HBrO in cells and water samples, but also was fabricated as a paper-based sensor. In consequence, SWJT-23 is expected to be an efficient and powerful tool for monitoring HBrO in organisms and the environment in realistic scenarios.
Keyphrases
- fluorescent probe
- living cells
- loop mediated isothermal amplification
- sensitive detection
- induced apoptosis
- cell cycle arrest
- quantum dots
- real time pcr
- label free
- cancer therapy
- climate change
- endoplasmic reticulum stress
- oxidative stress
- photodynamic therapy
- molecular dynamics
- energy transfer
- pi k akt
- drug delivery
- cell proliferation
- gram negative