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Extension of the 5-alkynyluridine side chain via C-C-bond formation in modified organometallic nucleosides using the Nicholas reaction.

Renata KaczmarekDariusz KorczyńskiJames R GreenRoman Dembinski
Published in: Beilstein journal of organic chemistry (2020)
Dicobalt hexacarbonyl nucleoside complexes of propargyl ether or esters of 5-substituted uridines react with diverse C-nucleophiles. Synthetic outcomes confirmed that the Nicholas reaction can be carried out in a nucleoside presence, leading to a divergent synthesis of novel metallo-nucleosides enriched with alkene, arene, arylketo, and heterocyclic functions, in the deoxy and ribo series.
Keyphrases
  • electron transfer
  • molecular docking
  • gram negative
  • ionic liquid
  • metabolic syndrome