Comparative Accuracy of the InBios Scrub Typhus Detect IgM Rapid Test for the Detection of IgM Antibodies by Using Conventional Serology.

Hugh W F KingstonStuart D BlacksellAmpai TanganuchitcharnchaiAchara LaongnualpanichBuddha BasnyatNicholas P J DayDaniel Henry Paris

Published in: Clinical and vaccine immunology : CVI (2015)

This study investigated the comparative accuracy of a recombinant 56-kDa type-specific antigen-based rapid diagnostic test (RDT) for scrub typhus for the detection of IgM antibodies by using conventional serology in well-characterized serum samples from undifferentiated febrile illness patients. The RDT showed high specificity and promising comparative accuracy, with 82% sensitivity and 98% specificity for samples defined positive at an IgM indirect immunofluorescence assay positivity cutoff titer of ≥1:1,600 versus 92% and 95% at ≥1:6,400, respectively.

Keyphrases

loop mediated isothermal amplification
end stage renal disease
newly diagnosed
ejection fraction
sensitive detection
label free
prognostic factors
real time pcr
high throughput
structural basis
mass spectrometry
patient reported
atomic force microscopy