UCH-L1 Inhibitor Alleviates Nerve Damage Caused by Moyamoya Disease.

Minghua Xu Xiaomin Zhao Jiang Zhao Zhisheng Tan Chengshi Zhang Yun Huang Huiping Zhong Meifeng Guo Chen Zhang Ping Ye Wentao Zheng

Published in: Applied bionics and biomechanics (2024)

UCH-L1 inhibitor could reverse MMD-induced inhibition of SH-SY5Y cell viability and promotion of apoptosis. UCH-L1 may be a therapeutic target for the treatment of nerve damage caused by MMD.

Keyphrases

oxidative stress
diabetic rats
peripheral nerve
high glucose
endoplasmic reticulum stress
cell death
middle cerebral artery
cell cycle arrest
mouse model
drug induced
combination therapy
endothelial cells
cell proliferation
replacement therapy