Comment on "Circadian rhythms in the absence of the clock gene Bmal1".

Katharine C AbruzziCédric GobetFelix Naef Michael Rosbash

Published in: Science (New York, N.Y.) (2021)

Ray et al (Reports, 14 February 2020, p. 800) recently claimed temperature-compensated, free-running mRNA oscillations in Bmal1 -/- liver slices and skin fibroblasts. We reanalyzed these data and found far fewer reproducible mRNA oscillations in this genotype. We also note errors and potentially inappropriate analyses.

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