Inactivation of pentraxin 3 suppresses M2-like macrophage activity and immunosuppression in colon cancer.
Feng-Wei ChenYung-Ling WuChao-Chun ChengYu-Wei HsiaoJhih-Ying ChiLiang-Yi HungChih-Peng ChangMing-Derg LaiJu-Ming Wang
Published in: Journal of biomedical science (2024)
PTX3 contributes to stromal cell-mediated protumor immunity by increasing M2-like macrophage polarization, and inhibition of PTX3 with WHC-001 is a potential therapeutic strategy for colon cancer.