Incidence of Malignancies Among Patients With Chronic Hepatitis B in US Health Care Organizations, 2006-2018.
Philip R SpradlingJian XingYuna ZhongLoralee B RuppAnne C MoormanMei LuEyasu H TeshaleMark A SchmidtYihe G DaidaJoseph A BoscarinoStuart C GordonPublished in: The Journal of infectious diseases (2022)
Hepatitis B virus (HBV) infection causes hepatocellular carcinoma but its association with other cancers is not well established. We compared age-adjusted incidence of primary cancers among 5773 HBV-infected persons with US cancer registries during 2006-2018. Compared with the US population, substantially higher incidence among HBV-infected persons was observed for hepatocellular carcinoma (standardized rate ratio [SRR], 30.79), gastric (SRR, 7.95), neuroendocrine (SRR, 5.88), cholangiocarcinoma (SRR, 4.62), and ovarian (SRR, 3.72) cancers, and non-Hodgkin lymphoma (SRR, 2.52). Clinicians should be aware of a heightened potential for certain nonhepatic malignancies among hepatitis B patients, as earlier diagnosis favors improved survival.
Keyphrases
- hepatitis b virus
- risk factors
- liver failure
- healthcare
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- papillary thyroid
- palliative care
- peritoneal dialysis
- childhood cancer
- young adults
- patient reported outcomes
- social media
- free survival
- health information
- patient reported