Association of Neighborhood Deprivation with White Matter Connectome Abnormalities in Temporal Lobe Epilepsy.
Daniel Y ChuNagesh AdluruVeena A NairTimothy ChoiAnusha AdluruCamille Garcia-RamosKevin DabbsJedidiah MathisAndrew S NenckaCarson GundlachLisa ConantJeffrey R BinderMary E MeyerandAndrew L AlexanderAaron F StruckBruce P HermannVivek PrabhakaranPublished in: Epilepsia (2023)
Our findings demonstrate: 1) the general impact of TLE on DWI connectome status is larger than the association with neighborhood disadvantage; however, 2) neighborhood disadvantage, indexed by ADI, revealed modest relationships to white matter structure and integrity on sensitivity analysis in TLE. Further studies are needed to explore this relationship and determine if the white matter relationship with ADI is driven by social drift or environmental influences on brain development. Understanding the etiology and course of the disadvantage-brain integrity relationship may serve to inform care, management, and policy for patients.
Keyphrases
- white matter
- multiple sclerosis
- healthcare
- physical activity
- resting state
- temporal lobe epilepsy
- end stage renal disease
- ejection fraction
- newly diagnosed
- public health
- palliative care
- prognostic factors
- functional connectivity
- pain management
- single cell
- magnetic resonance
- human health
- risk assessment
- blood brain barrier
- diffusion weighted imaging
- health insurance