Metabolic Dysfunction in New-Onset Idiopathic Intracranial Hypertension: Identification of Novel Biomarkers.

Johanne Juhl KorsbækRigmor Højland JensenDagmar BeierElisabeth Arnberg WibroeSnorre Malm HagenLaleh Dehghani MolanderMatthew Paul GillumKatrine SvartThomas Folkmann Hansen Lisette J A Kogelman Connar Stanley James Westgate

Published in: Annals of neurology (2024)

We identify perturbed metabolism in new-onset IIH. S1P and LysoPC-16 demonstrate potential prognostic value due to association with subsequent optic nerve atrophy. This association between specific, differential metabolites and outcome provides substantial evidence for novel biomarkers of clinical significance that should be the focus of further targeted studies. ANN NEUROL 2024;96:595-607.

Keyphrases

optic nerve
optical coherence tomography
blood pressure
ms ms
oxidative stress
cancer therapy
drug delivery
risk assessment