Behçet's disease (BD) is an inflammatory systemic vasculitis manifested by uveitis and oral and genital aphthae. There have been no reported cases in the literature about reduction mammoplasty or large flap surgeries in BD. A 55-year-old female with a 16-year history of BD was presented to our clinic for reduction mammoplasty. The patient was taking colchicine and had records of uveitis and oral and genital aphthae. Colchicine treatment was stopped one week before surgery and restarted one week later. Reduction mammoplasty was performed with the inferior pedicle technique. On the first day after surgery, mild hyperemia and induration were observed around the incision line, worsening over the next 48-72 hours with the appearance of serous discharge at the vertical suture line and inverted T incision. Minimal wound dehiscence developed on the seventh day, and a small superficial necrosis developed at the lower part of the vertical suture on the 15th day. Between days 30 and 45, the necrotic tissue sloughed off, and the wound closed with epithelialization. In conclusion, patients with BD may experience prolonged inflammation, small skin necroses around the incision line, and delayed wound healing post surgery, although acceptable scar maturation can eventually be achieved.