Adrenomedullin ameliorates podocyte injury induced by puromycin aminonucleoside in vitro and in vivo through modulation of Rho GTPases.

Nan DongLixia MengRuqun XueMeng YuZhonghua ZhaoXueguang Liu

Published in: International urology and nephrology (2017)

AM alleviated podocyte injury induced by PAN both in cell culture and in PAN nephrosis. The beneficial effects of AM on podocytes can be attributable to direct modulation of podocyte cytoskeletal proteins and Rho GTPases, mainly via a PKA-dependent pathway.

Keyphrases

diabetic nephropathy
high glucose
endothelial cells
protein kinase
smooth muscle