Impact of diabetes on remodelling, microvascular function and exercise capacity in aortic stenosis.
Abhishek DattaniEmer M BradyAseel AlfuhiedGaurav Singh GulsinChristopher D SteadmanJian L YeoSaadia AslamMarko BanovicMichael Jerosch-HeroldHui XuePeter KellmanPhilippe CostetMary Ellen CvijicLei ZhaoChristina EbertLaura LiuKushan GunawardhanaDavid GordonChing-Pin ChangJ Ranjit ArnoldThomas YatesDamian KellyKai HogrefeDana DawsonJohn Pierre GreenwoodLeong L NgAnvesha SinghGerry P McCannPublished in: Open heart (2023)
In patients with moderate-to-severe AS, diabetes is associated with reduced exercise capacity, increased diffuse myocardial fibrosis and microvascular dysfunction, but not cardiovascular events despite a small increase in mortality.
Keyphrases
- cardiovascular events
- cardiovascular disease
- aortic stenosis
- high intensity
- coronary artery disease
- left ventricular
- type diabetes
- transcatheter aortic valve replacement
- ejection fraction
- aortic valve replacement
- transcatheter aortic valve implantation
- aortic valve
- glycemic control
- resistance training
- physical activity
- oxidative stress
- low grade
- early onset
- high grade
- atrial fibrillation
- liver fibrosis
- risk factors
- insulin resistance
- weight loss