Multiplexed Assay to Quantify the PP-Fold Family of Peptides in Human Plasma Using Microflow Liquid Chromatography-Tandem Mass Spectrometry.
Gemma Reverter-BranchatPhilippe J EugsterChristina KuenzliBarbara RindlisbacherThomas StaufferChristos Theodoros NakasDavid HerzigEric GrouzmannLia BallyPublished in: Clinical chemistry (2022)
The assay allowed for specific multiplexed analysis of the PP-fold family of peptides and their DPP4-cleaved fragments in a single sample, thereby offering new perspectives to study the role and therapeutic potential of these essential peptide hormones in health and metabolic disease.